Lentinan AXT - Zenius Labs™
Two compounds. One force
Natural polysaccharides extracted from Lentinula Edodes medicinal mushroom has clinically shown the ability to inhibit tumor growth, prevent tumor metastasis, enhance radio and chemotherapy efficacy and help recover with fewer side effects.
Not opinions, just facts
Effect on Tumor:
Inhibit tumor growth 8, 19, 21, 1, 3, 20, 51, 39, 43, 18
Induce tumor cell apoptosis (promote mutated cell to die) 13, 6, 3, 50, 43
Block tumor angiogenesis (growing new blood vessels to sustain itself) 51, 3, 39
Prevent oncogenesis (new healthy cells mutating to divide relentlessly) 49, 7, 55
Prevent tumor metastasis (spreading to a other body parts) 7, 3
Effect on Immune System:
Increase immune response related to tumor cells 3, 11, 12, 34, 35
Decrease immune response related to allergies 27, 29, 3, 42, 34, 35
Up-regulate NK cell-mediated destruction of tumor cells (NK – Natural killer cells) 31, 30, 3, 4, 16, 11, 12, 22, 10
Activate macrophages (macrophages detect and destroy tumor cells) 3, 11, 10, 12, 16, 22, 24, 25, 26, 49
Stimulate production of Cytokines (cytokines – messengers between cells, coordinate immune response) 9, 16, 22, 10, 3, 4, 7, 11, 12
Augment lymphokine-activated killer cell activity 58, 57, 49
Activate T cells (T cells play a key role in the immune system in fighting cancer. Chemotherapy reduces T-cell count.) 11, 26, 31, 10
In combination with chemotherapy
Enhance effectiveness of chemotherapy 33, 15, 32, 38, 41, 44, 45, 43, 14, 23, 42, 47, 11
Help with chemotherapy side effects 3, 7, 45
Improves patients’ quality of life (QOL) 47, 3, 48, 23, 42
Prolongs the survival of patients, as compared to chemotherapy alone 3, 11, 36, 37, 38, 41, 44, 45, 53, 54.
Fungal polysaccharides (such as Lentinan) are natural and safe 45, 28, 42. These compounds are directly isolated from medicinal mushrooms, that were used as food for thousands of years.
Astaxanthin, despite having direct antitumor 62, 63, 64, 65, 66, 67 and chemoprotection 68, 69, 70, 71, 77 properties, is the strongest antioxidant known to science 72. Astaxanthin, a natural carotenoid from algae, repairs damaged DNA 73, 74, 75, protects cell membrane 76 and preserves mitochondrial integrity and function 61. Clinically, astaxanthin has shown diverse benefits, with excellent safety and tolerability 78.
Get Started With Lentinan AXT Today
Get your Cells back on track. Active compounds are clinically validated to impact your immune system, DNA and cell integrity.
Get Started with Lentinan AXT Today
Get your Cells back on track. Active compounds are clinically validated to impact your immune system, DNA and cell integrity.
Still Have Questions?
Sources
1. A polysaccharide from Lentinus edodes inhibits human colon cancer cell proliferation and suppresses tumor growth in athymic nude mice.
[Pubmed]
2. Inhibition of Growth and Induction of Apoptosis in Human Cancer Cell Lines by an Ethyl Acetate Fraction from Shiitake Mushrooms.
[ResearchGate]
3. Potential of Mushroom Compounds as Immunomodulators in Cancer Immunotherapy: A Review.
[Pubmed]
4. Dectin-1 mediates the biological effects of beta-glucans.
[Pubmed]
5. β-Glucans are involved in immune-modulation of THP-1 macrophages.
[Pubmed]
6. Lentinan inhibited colon cancer growth by inducing endoplasmic reticulum stress-mediated autophagic cell death and apoptosis.
[Pubmed]
7. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides.
[Pubmed]
8. In vitro cytostatic and immunomodulatory properties of the medicinal mushroom Lentinula edodes.
[Pubmed]
9. Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver.
[Pubmed]
10. Natural Polysaccharides and Their Derivates: A Promising Natural Adjuvant for Tumor Immunotherapy.
[Pubmed]
11. The Use of Lentinan for Treating Gastric Cancer.
[Pubmed]
12. Fungal beta-glucans and mammalian immunity.
[Pubmed]
13. Immunogenic Cell Death (ICD) of Murine H22 Cells Induced by Lentinan.
[Pubmed]
14. Lentinan combined with cisplatin for the treatment of non-small cell lung cancer.
[Pubmed]
15. Rituximab therapy of lymphoma is enhanced by orally administered (1–>3),(1–>4)-D-beta-glucan.
[Pubmed]
16. In vitro generation of activated natural killer cells and cytotoxic macrophages with lentinan.
[Pubmed]
17. Anticomplementary Activity of Antitumour Polysaccharides.
[Nature]
18. Fractionation and Purification of the Polysaccharides with Marked Antitumor Activity, Especially Lentinan, from Lentinus edodes (Berk.) Sing. (an Edible Mushroom).
[Pubmed]
19. Lentinan, a New Immuno-accelerator of Cell-mediated Responses.
[Nature]
20. The mechanisms of action of anti-tumour polysaccharides. I. The effects of antilymphocyte serum on the anti-tumour activity of lentinan.
[Wiley]
21. Inhibition of human colon carcinoma development by lentinan from shiitake mushrooms (Lentinus edodes).
[Pubmed]
22. Medicinal importance of fungal beta-(1–>3), (1–>6)-glucans.
[Pubmed]
23. Mushrooms and immunity.
[Pubmed]
24. Beta-glucan recognition by the innate immune system.
[Pubmed]
25. Activation of macrophages by linear (1right-arrow3)-beta-D-glucans. Impliations for the recognition of fungi by innate immunity.
[Pubmed]
26. Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.
[Pubmed]
27. Lentinan Inhibited the Activation of Th2 Cells in Allergic Mice by Reducing the Amplitude of Changes in Biological Rhythm.
[Pubmed]
28. beta(1 leads to 3) Glucan-mediated augmentation of alloreactive murine cytotoxic T-lymphocytes in vivo.
[Pubmed]
29. β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective effects – Implications for coronavirus disease (COVID-19) immunotherapies.
[Pubmed]
30. Effects of lentinan on cytotoxic functions of human lymphocytes.
[Pubmed]
31. Acting mechanisms of Lentinan in human–II. Enhancement of non-specific cell-mediated cytotoxicity as an interferon inducer.
[Pubmed]
32. Monoclonal antibody-dependent murine macrophage-mediated cytotoxicity against human tumors is stimulated by lentinan.
[Pubmed]
33. Orally administered beta-glucans enhance anti-tumor effects of monoclonal antibodies.
[Pubmed]
34. The skewing to Th1 induced by lentinan is directed through the distinctive cytokine production by macrophages with elevated intracellular glutathione content.
[Pubmed]
35. Immunoregulatory effects of the antitumor polysaccharide lentinan on Th1/Th2 balance in patients with digestive cancers.
[Pubmed]
36. Lentinan potentiates immunity and prolongs the survival time of some patients.
[Pubmed]
37. Lentinan prolonged survival in patients with gastric cancer receiving S-1-based chemotherapy.
[Pubmed]
38. Individual patient based meta-analysis of lentinan for unresectable/recurrent gastric cancer.
[Pubmed]
39. β-glucan from Lentinus edodes inhibits breast cancer progression via the Nur77/HIF-1α axis.
[Pubmed]
40. New ‘don’t eat me’ signal may provide basis for cancer therapies.
[Stanford.edu]
41. The use of lentinan for treating gastric cancer.
[Pubmed]
42. Effects of fungal beta-glucans on health – a systematic review of randomized controlled trials.
[Pubmed]
43. Lentinan reduces tumor progression by enhancing gemcitabine chemotherapy in urothelial bladder cancer.
[Pubmed]
44. Chemo-Immunotherapy Using Lentinan for the Treatment of Gastric Cancer with Liver Metastases.
[Pubmed]
45. Efficacy of biological response modifier lentinan with chemotherapy for advanced cancer: a meta‐analysis.
[Pubmed]
46. Supplementation with a soluble β-glucan exported from Shiitake medicinal mushroom, Lentinus edodes (Berk.) singer mycelium: a crossover, placebo-controlled study in healthy elderly.
[Pubmed]
47. Mushroom polysaccharide lentinan for treating different types of cancers: A review of 12 years clinical studies in China.
[Pubmed]
48. Effect of Beta glucan on quality of life in women with breast cancer undergoing chemotherapy: a randomized double-blind placebo-controlled clinical trial.
[Pubmed]
49. Antitumor and metastasis-inhibitory activities of lentinan as an immunomodulator: an overview.
[Pubmed]
50. Lentinan, A Shiitake Mushroom β-Glucan, Stimulates Tumor-Specific
Adaptive Immunity through PD-L1 Down-Regulation in Gastric Cancer
Cells.
[Medicinal chemistry]
51. Lentinan inhibits tumor angiogenesis via interferon γ and in a T cell independent manner.
[Pubmed]
52. [TS-1 and lentinan combination immunochemotherapy for advanced or recurrent gastric cancer: a preliminary report].
[Pubmed]
53. Lentinan potentiates immunity and prolongs the survival time of some patients.
[Pubmed]
54. [Relationship between prolonged life span and changes of serum IAP and albumin induced by the therapy of lentinan plus tegafur in inoperable and recurrent gastric cancer].
[Pubmed]
55. Anticancer polysaccharides from natural resources: a review of recent research.
[Pubmed]
56. The effect of lentinan combination therapy for unresectable advanced gastric cancer.
[Pubmed]
57. Induction of endogenous lymphokine-activated killer activity by combined administration of lentinan and interleukin 2.
[Pubmed]
58. Augmentation of lymphokine-activated killer cell activity by lentinan.
[Pubmed]
59. Lentinan inhibits tumor angiogenesis via interferon γ and in a T cell independent manner.
[BioMedCentral]
60. Astaxanthin protects oxidative stress mediated DNA damage and enhances longevity in Saccharomyces cerevisiae.
[Pubmed]
61. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential.
[Pubmed]
62. Anti-Tumor Effects of Astaxanthin by Inhibition of the Expression of STAT3 in Prostate Cancer.
[Pubmed]
63. Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review.
[Pubmed]
64. Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma.
[Pubmed]
65. Astaxanthin Modulates Apoptotic Molecules to Induce Death of SKBR3 Breast Cancer Cells.
[Pubmed]
66. Astaxanthin targets PI3K/Akt signaling pathway toward potential therapeutic applications.
[Pubmed]
67. Astaxanthin induces apoptosis and increases activity of antioxidant enzymes in LS-180 cells.
[Pubmed]
68. Dietary carotenoids in cancer chemoprevention and chemotherapy: A review of emerging evidence.
[Pubmed]
69. Astaxanthin intervention ameliorates cyclophosphamide-induced oxidative stress, DNA damage and early hepatocarcinogenesis in rat: role of Nrf2, p53, p38 and phase-II enzymes.
[Pubmed]
70. Intervention of astaxanthin against cyclophosphamide-induced oxidative stress and DNA damage: a study in mice.
[Pubmed]
71. Astaxanthin inhibits cytotoxic and genotoxic effects of cyclophosphamide in mice germ cells.
[Pubmed]
72. Mitochondrion-Permeable Antioxidants to Treat ROS-Burst-Mediated Acute Diseases.
[Pubmed]
73. Rat Glioma Cell-Based Functional Characterization of Anti-Stress and Protein Deaggregation Activities in the Marine Carotenoids, Astaxanthin and Fucoxanthin.
[Pubmed]
74. Protective effects of astaxanthin on skin: Recent scientific evidence, possible mechanisms, and potential indications.
[Pubmed]
75. Protective effects of ginsenoside Rg2 and astaxanthin mixture against UVB-induced DNA damage.
[Pubmed]
76. Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging.
[Pubmed]
77. The Role of the Reactive Oxygen Species Scavenger Agent, Astaxanthin, in the Protection of Cisplatin-Treated Patients Against Hearing Loss.
[Pubmed]
78. Astaxanthin in Liver Health and Disease: A Potential Therapeutic Agent.
[Pubmed]